Institute of Clinical Immunology and Allergology

First Faculty of Medicine
Charles University and General University
Hospital in Prague

jackovaev 06.05.2025

Informations

Our lab focuses on the understanding of fine-tune regulation of homeostatic interaction between microbiota and host immune system. Specifically, how changes in microbiota composition and function are changing immune responses. Special attention is paid to the early postnatal period when both microbiota and immune system are developing, and mutual homoeostatic interactions are being set. Caesarean section delivery and early postnatal antibiotics administration impact microbiota development, thus delaying neonatal immune system maturation. Probiotic administration seems to be a rational way for promoting immune system maturation and/or a correction for dysbiosis.


Master student

Master students are welcome to apply to perform a diploma thesis in our laboratory.
Master students can choose from multiple themes carried out in the laboratory to work on.

Postgraduate students

Postgraduate students can choose from multiple themes based on the grants available and their research interests.

Current open project for Ph.D. students

  • The role of dysbiosis on proportional and functional characteristics of particular neutrophil subsets
  • Role of neutrophils in health and disease
  • Effect of early postnatal probiotic supplementation on maturation of neonatal immune system